Age-old wisdom and
Modern Biotechnology Convergence
BioZak Botanicals like a hand-full other
corporations is utilizing its biotech expertise in developing dietary
supplements from the age-old wisdom. BioZak uses its rigorous drug
discovery methods and assays systems to re-confirm effectiveness of the
herbs. BioZak also investigates short-term and long-term cumulative
side effects (if any) of the herbs on cells.
Company uses its proprietary formulation
technologies in producing herbal supplements that synergistically
enhance body’s structure –function and helps people to enjoy good health
and sound spirit—BioZak just not in business for products- we are for
There are thousands of products from thousands of
manufactures across the internet space and physical vitamin stores.
Many of these products have strong anecdotal evidence and grandmother’s
testimonial of century old usages. Some of those products do provide
useful support to the body’s structure function. However, many of those
products fall short on wholistic-wellness aspect.
Drug Discovery Processes
In a natural product drug-discovery process,
researchers in a biotechnology laboratory first extract the herbs and
then fractionate the extracts using separation columns or other
In the next step, research scientists perform
multiple assays to identify, which fraction is most effective and which
fraction is non-toxic to the cells (body). After that they try to
identify how many molecules in that fractions and what are the formulas
of the molecule. And then go on to see if they can make them chemically
for commercial-economical reasons
Human body made of millions of cells and each cell
is capable of living and regenerating itself for long time – provided it
is not challenged by the environments-internal and external. Internal
environment is mostly control by the immune system that triggered by the
external stimuli such as chemicals, radiation, pollutants, food, germs
–virus, bacteria; and emotional (mind) status. Time – the aging process
also contributes to the immune system’s functionality
One can keep the cell functions active and proper
by managing the surrounding environment, keeping sound emotional health
and working with the immune system. One can achieve most of the above
requirement by being in a good social and political environment, regular
exercise and well-balance food regime. If one can do that they may not
need any products others or we produce.
Body is in perfect balance within the internal
cell-environment and with the external environment. If these balance
moves to words the non-equilibrium side, one begin to sees or fells
physical and/or emotional difficulties. It is thus important to bring
the body’s cell system to the equilibrium (balanced) state. If one
keeps all the body’s structure function in the balanced state, he/she
will seldom feel any physical or emotional difficulties.
Several important systems that work perfect in
balance systems are: Immune systems, hormonal systems (endocrine), nerve
systems, blood and circulatory system and others.
Scientific community has studied immune system
imbalance most extensively because the immune systems account for
many diseases directly and indirectly. Immune system is also controls
part of the aging process. Some of the medical systems due to immune
system’s imbalance are: Autoimmune diseases (arthritis, rheumatism,
diabetes), pathogenic infections, Allergic reactions, atopy- eczema, and
Endocrine system is another system that
draws great interest from the research and business community.
Imbalance of this system quite often associated with the environmental
factors such as –stress, anxiety, work-pressure and aging. Endocrine
system also varies with the gender. Some the physiological syndrome may
arise due to the imbalance of the endocrine systems are: sleeping
problems, mood-imbalance, emotional-status, menopause, PMS, prostate
enlargement and urinary problems.
Most of the body’s structure-function can be
brought in to the balanced state by maintaining regular regime of
exercise, and balanced diet. Additional support may be achieved from
focus is on (1) Anti-Inflammatory, and (2) Endocrine hormone related
BioZak Botanical Inc.
has identified the natural extracts of botanical plants that had been
used for a long time in ethno-herbal medicine to control immunological
disorders such as Allergy, asthma and cough. As the supply of the
natural is very limited, we have developed a proprietary
biotechnological process to enable its cultivation in large quantity to
ensure regular commercial supply of food grade quality.
Natural extracts shows
evidence of good efficacy in the treatment of asthma, allergic rhinitis
and cough in experimental animals. In animal experiments, it improves
pulmonary functions, inhibits airway hyper-responsiveness, suppresses
the rise of eosinophiles and modulates IL-4 and INF-gamma levels in
bronchoalveolar lavage fluid (BALF). It proves itself effective in
cough suppression, and in promoting airway clearance.
inhibits mast cell degranulation, and the release of leucotrienes. It
relaxes lung strip contraction but does not seem to have significant
anti-histaminic effect on airway smooth muscle. We also have
experiments showing its enhancing effect on ciliary activity in frog
esophagus and rabbit airway.
The mechanism of
action is probably via modulation and restoration of Th1 and Th2 balance
(INF-gamma versus IL-4) and inhibition of the 5-lipoxygenase pathway of
arachidonic acid metabolism (inhibition of leucotrienes).
inhibited the increased lung resistance and the decreased lung
compliance induced by antigen challenge, significantly reduced total
cell counts and absolute eosinophil counts in BALF; They also inhibited
recruitment of inflammatory cells in peritoneal lavage fluid and
inhibited the allergen-induced mast cell degranulation. Thus, the
extracts inhibit airway hyper-responsiveness by stabilizing mast cell
membranes and reducing infiltration and chemotaxis of eosinophils.
controls many physiological functions. It is important to keep the
endocrine hormone level balanced at all-time. Modern hectic life-style
and high demand on metal and physical systems always puts pressure on
the hormonal systems. As a result, people faced with stress,
frustration, anxiety and sleeping problem. Endocrine system also
becomes imbalanced as our physiological body aged. Some of the
well-known symptoms are prostate enlargement for men and menopause
related hot flashes, night sweats.
BioZak Botanical has
been working on several natural plant and herb extracts that have shown
to balance endocrine hormonal-system. These extracts are of “functional
food” category and available in natural food stores. BioZak Botanical
has utilized its proprietary biotechnological processing methods and
formulation techniques in developing its products for balancing
endocrine hormonal system.